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. 2016 Oct 17;10:232. doi: 10.3389/fncel.2016.00232

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Copyright © 2016 Hong, Tian, Yuan, Qi, Li, Du, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of a reactive oxygen species (ROS) scavenger and an nNOS inhibitor on GSK1016790A-induced neuronal injury. (A) Injection of the TRPV4 agonist GSK1016790A reduced the number of surviving cells in the hippocampal CA1 area, which was significantly attenuated by the ROS scavenger Trolox and the nNOS inhibitor ARL-17477. Scale bar = 50 μM. (B) More Hoechst⁺ cells (white stars) were found in the hippocampal CA1 area in the GSK1016790A-injected mice, which was markedly blocked by Trolox and ARL-17477. Scale bar = 50 μM. **P < 0.01 vs. control, ^##P < 0.01 vs. GSK1016790A.