Table 2.

VNTR-DAT1 and COMTVal158Met effects on cognitive and functional variables in the TESDAD DS population.

Test	Function assessed	Polymorphism	Figure	Estimate	Standard error	t-value	p-value
SSP-FR (CANTAB)	Mean time to response	VNTR-DAT	Figure 1A	537	270	1.999	0.05
SRT (CANTAB)	Mean time to respond	VNTR-DAT	Figure 1B	117	48	2.424	0.018
MOT(CANTAB)	Mean time to respond	VNTR-DAT		137	77	1.772	0.081
SFWGT	Switching ability: MF	VNTR-DAT	Figure 1C	–1.5	0.5	–3.265	0.002
WCFST	Reversal learning: MF	VNTR-DAT		–0.8	0.4	–1.921	0.059
SFWGT	Switching ability: MF	COMTVal158Met	Figure 2A	–1.4	0.5	–2.935	0.005
ABAS-Social Skills	Adaptive social behavior	COMTVal158Met	Figure 2B	6.99	2.9	2.453	0.017
ABAS-Self-Direction	Capacity of regulate behavior to the demands of a situation.	COMTVal158Met	Figure 2C	7.65	3.7	2.08	0.041
DMR-SOS	Social symptoms of dementia	COMTVal158Met	Figure 2D	–2.1	1	–2.108	0.039

SSP, Spatial Span; FR, Forward Recall; SRT, Simple Reaction Time; MOT, Motor Screening; SFWGT, Semantic Fluency Word Generation Task; WCFST, Weigl Color-Form Sort Test; CANTAB, Cambridge Neuropsychological Test Automated Battery; DMR-SOS, Dementia Questionnaire for Persons with Intellectual Disabilities (Sum of Social Scores); ABAS, Adaptive Behavior Assessment System; MF, mental flexibility; Estimate, estimated mean difference; Standard Error, standard error of the estimated mean difference; t-value, Value of the t-statistics; F, Figure; G, Graphic. Two-way ANOVA model was carried out to analyse main differences between allelic groups of each polymorphism regarding cognitive and functional outcomes.

Statistically significant associations above a significance level of 0.05 are represented as bold values.