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. 2016 Oct 17;3:86. doi: 10.3389/fvets.2016.00086

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Copyright © 2016 Samir, Vaas and Pessler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNAs that are regulated in IAV infection in humans, chicken, pig, and mice. (A) Venn diagram depicting miRNAs that are differentially and commonly expressed in the four species. (B) Heat map showing the pathways regulated by two of the three miRNAs regulated in all four species. (C) Sequence alignment of the premature form of miR-223, a well characterized miRNA that is regulated in all four species. While the mature form of this miRNA is highly conserved across the four species (represented by stars above the sequences), the premature form shows a lesser degree of conservation. The seed region is highlighted in gray.