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. 2016 Oct 17;7:422. doi: 10.3389/fimmu.2016.00422

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Copyright © 2016 Brooks, Lawson, Rytych, Yu, Janda, Steelman and M^cCusker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo, hippocampal Ido1 expression is increased after LPS and pI:C administration. Mice were administered saline (Ctrl), LPS, or pI:C and hippocampi collected after 6 h. Gene expression of three Ido1 transcripts was measured. Expression levels are relative to Ctrl samples normalized to 1.0. *p < 0.05 for the effect of LPS or pI:C. Average Ctrl C_t values for each transcript: (A) Ido1-FL: C_t = 40.0, (B) Ido1-v1: C_t = 29.8, and (C) Ido1-v2: C_t = 39.7. C_t values indicate that Ido1-FL and Ido1-v2 are essentially not expressed in naive (Ctrl) mouse hippocampi, whereas Ido1-v1 expression is detectable in all samples.