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. 2016 Oct 17;7:422. doi: 10.3389/fimmu.2016.00422

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Copyright © 2016 Brooks, Lawson, Rytych, Yu, Janda, Steelman and M^cCusker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific Ido2 transcripts expressed in the mouse hippocampus are increased by LPS and pI:C in vivo. Mice were administered saline (Ctrl), LPS, or pI:C and hippocampi were collected after 6 h. Expression of six Ido2 gene transcripts was measured. Expression levels are relative to Ctrl samples set to 1.0. *p < 0.05 for the effect of LPS or pI:C. Average Ctrl C_t values for each transcript: (A) Ido2-v1: C_t = 29.2, (B) Ido2-v2: C_t = 28.9, (C) Ido2-v3: C_t = 28.4, (D) Ido2-v4: C_t = 38.5, (E) Ido2-v5/-v2: C_t = 31.6, and (F) Ido2-v6/-v2: C_t = 28.3. C_t values indicate that Ido2-FL (non-detectable, not shown) and Ido2-v4 are essentially not expressed in naive (Ctrl) mouse hippocampi. Expression of other Ido2 transcripts are readily detectable in all samples.