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. 2016 Oct 17;9:98. doi: 10.3389/fnmol.2016.00098

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Copyright © 2016 Kobeissy, Hansen, Neumann, Fu, Jin and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VEGF induces Cofilin1 phosphorylation in Emx1^+/+ NSCs. (A) Western blot analysis of NSC lysates for p-Cofilin1, Cofilin1, VEGF receptor 2 FLK and actin from both Emx1 genotypes treated with VEGF (V) (50 ng/ml) or medium (C) for 1 h in the presence EGF, or EGF+FGF as indicated. VEGF increased the level of p-Cofilin1in the Emx1^+/+ NSCs cultured in EGF or EGF+FGF, compared to those treated with medium (^*p < 0.05). In contrast, Emx1^−/− NSCs expressed significantly less amount of p-Cofilin1 whether in the absence (^**p < 0.01) or presence of VEGF (^***p < 0.005), compared to that of the Emx1^+/+ NSCs (B). VEGF increased FLK expression only in the Emx1^+/+ NSCs (C, ^*p < 0.05). N = 3/group.