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. 2016 Oct 17;7:357. doi: 10.3389/fphar.2016.00357

Figure 2.

Figure 2

Hup A provides robust protection against 6 Hz-induced seizures in Scn1a mutants and wild-type (WT) littermates. (A,B) Hup A conferred robust protection against 6 Hz-induced seizures (24 mA) in male Scn1aRH/+ mutants (N = 9–12/treatment) when administered at 0.5 mg/kg (A) and 1 mg/kg (B). (C) Although not statistically significant, when the current was doubled to 48 mA, Hup A (1 mg/kg) reduced the number of Scn1aRH/+ mutants that seized and decreased seizure severity when compared to vehicle-treated mutants. (D) Hup A (0.5 mg/kg) conferred robust seizure protection to male Scn1a+/− mutants and WT littermates at 20 mA (N = 8–11/treatment/genotype). (E,F) Hup A (1 mg/kg) effectively increased resistance to 6 Hz-induced seizures in Scn1a+/− mutants and WT littermates at 20 mA (E) and 40 mA (F). One-way rANOVA followed by Dunn's multiple comparisons post-hoc analyses. *p < 0.05, **p < 0.01, ***p < 0.001.