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| Resistance to | Rescue therapy |
|---|---|
| Lamivudine | Tenofovir |
| Telbivudine | Tenofovir |
| Entecavir | Tenofovir (or tenofovir + entecavir) |
| Adefovir | Entecavir (or tenofovir) |
| Tenofovir | Entecavir (or tenofovir + entecavir) |
| Multiple drugs | Tenofovir + entecavir |
Typical treatment options for the management of HBV antiviral resistance. In most cases, the switch to a monotherapy with a noncross-resistance profile is sufficient. HBV, hepatitis B virus.
