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| compd | TPSA (Å2) | HBD | LogD7.4 | MDCKa Papp A:B (10–6 cm/s)/ratio (A:B/B:A) | mouse PPB (%) |
|---|---|---|---|---|---|
| 2 | 46 | 2 | 1.4 | 9.4/0.5 | 99.3 |
| 4 | 46 | 2 | 0.8 | 7.4/1.0 | ND |
| 16 | 67 | 3 | –0.3 | 0.5/1.8 | ND |
| 18 | 58 | 3 | 2.4 | 1.0/2.8 | >99.9 |
| 25 | 49 | 2 | 2.1 | 1.7/0.9 | >99.9 |
| 29-R | 58 | 2 | 0.6 | 3.4/0.9 | 99.1 |
| 31 | 58 | 2 | 1.3 | 6.0/1.4 | >99.9 |
The MDCK assay23 was used as an indicator of cell permeability.
