Table 1. Inhibitory Activities of Compounds Against Tumor Cell Lines.
| IC50a (μM) |
|||||
|---|---|---|---|---|---|
| compd | PC-3 | MCF-7 | HEL | K562 | MOLT4 |
| 3a | 2.57 ± 0.22 | 1.93 ± 0.02 | 1.53 ± 0.15 | 1.70 ± 0.27 | 1.37 ± 0.23 |
| 3b | 5.38 ± 0.62 | 3.66 ± 1.29 | 5.93 ± 0.01 | >8.3b | >5 |
| 3c | 1.03 ± 0.25 | 1.87 ± 0.01 | 1.18 ± 0.15 | 1.86 ± 0.29 | 3.28 ± 0.45 |
| 3d | 2.30 ± 0.98 | NDc | 1.76 ± 0.24 | 2.08 ± 0.33 | ND |
| 3e | 1.13 ± 0.08 | 1.10 ± 0.01 | 1.24 ± 0.19 | 1.29 ± 0.21 | 1.26 ± 0.15 |
| 3f | 1.08 ± 0.05 | 1.33 ± 0.42 | 1.08 ± 0.06 | 0.77 ± 0.05 | 1.61 ± 0.35 |
| 3k | 10.38 ± 0.97 | ND | 3.96 ± 1.05 | 3.79 ± 0.86 | ND |
| 11b | 4.47 ± 1.29 | >5 | 0.35 ± 0.07 | 0.37 ± 0.11 | >5 |
| 11d | 13.52 ± 1.98 | >5 | ND | 3.72 ± 0.71 | >5 |
| 6d | ND | >5 | 9.71 ± 0.99 | >8.3 | ND |
| Ruxolitinib | >5 | >5 | 2.62 ± 0.19 | 10.3 ± 0.3 | 15.8 ± 1.4 |
a
IC50 are mean of two or three experiments, and standard deviation is given.
b
IC50 value of this compound is larger than 8.3 or 5.
c
ND, not determined.