Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| entry | sPLA2-IIa IC50 (μM) | plasma ICu,50 (μM)a | Fu (%) | LE/LLEb |
|---|---|---|---|---|
| varespladib | 0.028 | 0.008 | 12.5 | 0.37/7.2 |
| 1 | 24 | 0.9 | 1.8 | 0.39/2.2 |
Calculated as plasma sPLA2 IC50 (μM) × compound’s unbound fraction in human plasma (Fu)/100. Fu = 100 – human protein binding (%).
Ligand efficiency, LE (kcal/mol/HAC), calculated as −RT ln(sPLA2-IIa IC50)/heavy atom count. Ligand lipophilicity efficiency (LLE) calculated as pIC50 (sPLA2-IIa) – logD.
