Scheme 1. Schematic Representation of the Synergistic Mechanism of Cisplatin and a PP2A Inhibitor, LB.

P-Akt, phosphorylated Akt; P-Plk-1, phosphorylated polo-like kinase 1; MDM2, murine double minute 2; TCTP, translationally controlled tumor protein; P-ERK, phosphorylated extracellular regulated protein kinases.