Table 1.
The 25 most strongly up- and down-regulated genes in the liver of cows of the CLA group compared to the control group.
| Up-regulated in the CLA group |
Down-regulated in the CLA group |
||
|---|---|---|---|
| Gene symbol (gene title) | FC | Gene symbol (gene title) | FC |
| FXYD2 (FXYD domain containing ion transport regulator 2) | 2.21 | SLC2A5 (solute carrier family 2/facilitated glucose/fructose transporter), member 5) | − 2.69 |
| RNF144B (ring finger protein 144B) | 1.59 | MYH10 (myosin, heavy chain 10, non-muscle) | − 1.73 |
| LGALS3 (lectin, galactoside-binding, soluble, 3) | 1.56 | MT2A (metallothionein 2A) | − 1.70 |
| LAMP1 (lysosomal-associated membrane protein 1) | 1.56 | CA13 (carbonic anhydrase XIII) | − 1.65 |
| CDH11 (cadherin 11, type 2, OB-cadherin) | 1.54 | LOC100140338 (similar to nuclear antigen Sp100) | − 1.63 |
| ASPN (aspirin) | 1.51 | AK3L1 (adenylate kinase 3-like 1) | − 1.60 |
| GPM6A (glycoprotein M6A) | 1.51 | CATSPERG (cation channel, sperm-associated, gamma) | − 1.57 |
| TMEM167A (transmembrane protein 167A) | 1.51 | CPA1 (carboxypeptidase A1) | − 1.48 |
| EIF2A (eukaryotic translation initiation factor 2A, 65 kDa) | 1.49 | LOC781494 (similar to Myeloid-associated differentiation marker) | − 1.39 |
| IRX3 (iroquois homeobox 3) | 1.47 | ARF6 (ADP-ribosylation factor 6) | − 1.38 |
| KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) | 1.47 | PGCP (plasma glutamate carboxypeptidase) | − 1.36 |
| LOC100137763 (hypothetical protein LOC100137763) | 1.46 | NFKBIE (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon) | − 1.36 |
| CRP (C-reactive protein, pentraxin-related) | 1.44 | RGS9BP (regulator of G protein signaling 9 binding protein) | − 1.36 |
| ACYP2 (acylphosphatase 2, muscle type) | 1.43 | ZAP70 (zeta-chain (TCR) associated protein kinase 70 kDa) | − 1.35 |
| ACSL3 (acyl-CoA synthetase long-chain family member 3) | 1.42 | SKAP1 (src kinase associated phosphoprotein 1) | − 1.35 |
| BHMT (betaine–homocysteine S-methyltransferase) | 1.42 | AARSD1 (alanyl-tRNA synthetase domain containing 1) | − 1.34 |
| MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) | 1.42 | KLHDC4 (kelch domain containing 4) | − 1.34 |
| CA4 (carbonic anhydrase IV) | 1.40 | CEP110 (centrosomal protein 110 kDa) | − 1.34 |
| NRP1 (neuropilin 1) | 1.40 | C9orf100 (vav-like protein C9orf100 homolog) | − 1.34 |
| SMEK2 (SMEK homolog 2, suppressor of mek1) | 1.39 | CYP17A1 (steroid 17-alpha-hydroxylase/17,20 lyase) | − 1.33 |
| FBP1 (fructose-1,6-bisphosphatase 1) | 1.39 | SERPINB6 (serpin peptidase inhibitor, clade B (ovalbumin), member 6) | − 1.33 |
| ATE1 (arginyltransferase 1) | 1.39 | LOC100139934 (similar to zinc finger protein 90) | − 1.32 |
| ACSM3 (acyl-CoA synthetase medium-chain family member 3) | 1.38 | CSNK1G2 (casein kinase 1, gamma 2) | − 1.32 |
| SCOC (short coiled-coil protein) | 1.38 | B3GALT2 (UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2) | − 1.32 |
| AHSG (alpha-2-HS-glycoprotein) | 1.38 | OLFML1 (olfactomedin-like 1) | − 1.32 |