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. 2016 Sep 1;30(17):1943–1955. doi: 10.1101/gad.283499.116

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© 2016 Liu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Stromal SMO ablation accelerates pancreatic ADM and cellular proliferation. (A) Dual-color IHC for SMO (brown) and SMA (red) and quantification of SMO levels in fibroblast and epithelial cell compartments. Unmixed composite and component images of dual-color IHC and colocalization map showing SMA and SMO overlap in yellow. Bars, 50 μm. n = 3. Error bars represent means ± standard deviation (SD). (B) Dual-color IHC for β-amylase (red) and cytokeratin 19 (CK19; brown) and quantification of ADM lesions. KS control mice were compared with KCS experimental mice, and each dot represents one individual mouse. The red bar represents the median of each genetic group. Bars, 25 μm. (C) Dual-color IHC and quantitation for SMA (red) and Ki67 (brown) for fibroblasts (left graph) and ductal-like cells (right graph). Bars, 25 μm. (***) P < 0.001; (ns) not significant.