1A |
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See below |
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1B |
Normal distribution |
Two-way ANOVA (stress treatment × virus type) |
Main effect of virus type: p = 0.0044 |
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Main effect of stress treatment: p < 0.0001 |
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Sidak’s multiple-comparisons test |
Interaction: p < 0.0001 |
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Home cage–inescapable Stress |
95% CI: |
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eYFP |
30.24–58.97 |
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NpHR |
−7.976 to 20.10 |
2B |
Normal distribution |
Two-way repeated-measures ANOVA |
Main effect virus type: p = 0.0007 |
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Sidak’s multiple comparisons test |
Main effect time: p < 0.0001 |
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eYFP – NpHR |
Interaction: p = 0.0002 |
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BL1 |
95% CI: |
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BL2 |
−43.11 to 65.40 |
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BL3 |
−59.67 to 48.84 |
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BL4 |
−47.73 to 60.78 |
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S1 |
−66.85 to 41.66 |
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S2 |
33.82–142.3 |
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S3 |
−9.440 to 99.07 |
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S4 |
7.267–115.8 |
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S5 |
1.613–110.1 |
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PS1 |
0.8602–109.4 |
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PS2 |
−5.678 to 102.8 |
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PS3 |
13.43–121.9 |
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PS4 |
2.628–111.1 |
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Independent samples t test (AUC) |
0.5271–109.0 |
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T, df |
p = 0.0023 |
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|
t = 3.859 df = 12.00 |
2C |
Normal distribution |
Independent-samples t test for baseline JSI 5-HT values |
Maine effect virus type: p = 0.0029 |
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Two-way repeated-measures ANOVA |
Main effect time: p < 0.0001 |
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Sidak’s multiple-comparisons test |
Interaction: p < 0.0001 |
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eYFP – NpHR |
95% CI: |
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BL1 |
−31.60 to 60.99 |
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BL2 |
−32.35 to 60.23 |
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BL3 |
−67.83 to 24.76 |
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BL4 |
−41.90 to 50.69 |
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JSI |
78.49–171.1 |
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PI1 |
−9.353 to 83.23 |
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PI2 |
−34.55 to 58.03 |
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PI3 |
−25.61 to 66.98 |
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Independent-samples t test (AUC) |
p = 0.0102 |
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T, df |
t = 3.580 df = 6.479 |
2D |
Normal distribution |
Independent-samples t test |
p < 0.0001 |
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T, df |
t = 6.344 df = 9.716 |
2D |
Normal distribution |
Linear regression |
p = 0.0125 |
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|
R2 = 0.3921 |
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|
R = −0.6257 |
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T, df |
t = 6.344 df = 9.716 |
3 |
Normal distribution |
Ordinary one-way ANOVA |
p = 0.0065 |
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Tukey’s post hoc test |
95% CI |
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MHb Fos 0 h |
0.03556 to 2.589 |
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HC vs ES |
0.4731 to 3.027 |
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HC vs IS |
-0.8394 to 1.714 |
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ES vs IS |
p < 0.0001 |
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LHbM Fos 0 h |
−37.59 to −19.54 |
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HC vs ES |
−34.15 to −16.10 |
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HC vs IS |
−5.587 to 12.46 |
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ES vs IS |
p = 0.1416 |
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LHbL Fos 0 h |
p = 0.3300 |
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MHb Fos 2 h |
p = 0.0013 |
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LHbM Fos 2 h |
95% CI: |
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HC vs ES |
−38.21 to −8.789 |
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HC vs IS |
−34.40 to −4.977 |
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ES vs IS |
−10.90 to 18.52 |
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LHbL Fos 2 h |
p = 0.1888 |
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MHb Fos 4 h |
p = 0.8780 |
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LHbM Fos 4 h |
p = 0.8652 |
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LHbL Fos 4 h |
p = 0.0348 |
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HC vs ES |
95% CI: |
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HC vs IS |
−3.706 to 0.4562 |
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ES vs IS |
−4.331 to −0.1688 |
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|
−2.706 to 1.456 |
4 |
Normal distribution |
Ordinary one-way ANOVA |
95% CI: |
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Tukey’s post hoc test |
p = 0.6651 |
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Total FG MHb |
p = 0.7163 |
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Total FG LHbM |
p = 0.5220 |
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Total FG LHbL |
p = 0.9074 |
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Total Fos-IR MHb |
p < 0.0001 |
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Total Fos-IR LHbM |
95% CI: |
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HC vs ES |
−16.94 to −6.726 |
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HC vs IS |
−18.73 to −8.517 |
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ES vs IS |
−6.899 to 3.316 |
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Total Fos-IR LHbL |
p = 0.0109 |
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HC vs ES |
95% CI: |
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HC vs IS |
−8.395 to −1.022 |
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ES vs IS |
−7.020 to 0.3534 |
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Total % double-label MHb |
−2.312 to 5.062 |
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Total % double-label LHbM |
p = 0.4152 |
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HC vs ES |
p < 0.0001 |
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HC vs IS |
95% CI: |
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ES vs IS |
−21.49 to −7.661 |
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Total % double-label LHbL |
−18.44 to −4.614 |
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|
−3.866 to 9.960 |
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|
p = 0.0764 |