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. 2016 Oct 17;2:16078. doi: 10.1038/cddiscovery.2016.78

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Heat maps and hierarchical clusters of core apoptosis-related and glutathione metabolism-related genes up- and downregulated significantly in 1 μM (a) and 10 μM (b) arsenic-treated cells as compared with control. An arsenic treatment of 1 μM demonstrates 15 downregulated and 13 upregulated genes, whereas 10 μM treatment of arsenic-treated cells exhibits 37 upregulated and 7 downregulated genes as compared with control.