TABLE I. Minimum inhibitory (MIC) concentration values, antimicrobials testing range and breakpoints applied for SA7112 antimicrobial profiling.
| Antibiotics | Testing Range (µg/mL) | MIC (µg/mL) | MIC Breakpoints | ||
|---|---|---|---|---|---|
|
| |||||
| Susceptible | Intermediate | Resistant | |||
| Penicillin | 0.12 - 8.0 | > 8.0 | ≤ 0.12 | - | ≥ 0.25 |
| Oxacillin | 0.25 - 4 | > 4.0 | ≤ 2.0 | - | ≥ 4.0 |
| Ampicillin | 0.12 - 16 | 16.0 | ≤ 0.25 | - | ≥ 0.5 |
| Ceftiofur | ≤ 0.25 - 2.0 | > 8.0 | ≤ 2.0 | 4.0 | ≥ 8.0 |
| Vancomycin | 0.25 - 16 | 8.0 | ≤ 4.0 | 8.0 - 16.0 | ≥ 32.0 |
| Spectinomycin | 8.0 - 64.0 | > 64.0 | ≤ 32.0 | - | ≥ 64.0 |
| Streptomycin | 1000 | > 1000 | - | - | > 1000 |
| Erythromycin | 0.25 - 4.0 | > 4.0 | ≤ 0.5 | 1.0 - 4.0 | ≥ 8.0 |
| Tylosin | 0.5 - 32.0 | > 32.0 | ≤ 1.0 | 2.0 - 4.0 | ˃ 4.0 |
| Tilmicosin | 4.0 - 64.0 | > 64.0 | ≤ 16.0 | - | ≥ 32.0 |
| Tulathromycin | 1.0 - 64.0 | > 64.0 | ≤ 16.0 | 32.0 | ≥ 64.0 |
| Tetracycline | 2.0 - 16.0 | > 16.0 | ≤ 4.0 | 8.0 | ≥ 16.0 |
| Chlortetracycline | 0.5 - 8.0 | > 8.0 | ≤ 0.5 | 1.0 | ≥ 2.0 |
| Oxytetracycline | 0.5 - 8.0 | > 8.0 | ≤ 0.5 | 1.0 | ≥ 2.0 |
| Moxifloxacin* | 0.25 - 4.0 | > 4.0 | ≤ 0.5 | 1.0 | ≥ 2.0 |
| Levofloxacin* | 0.25 - 4.0 | > 4.0 | ≤ 1.0 | 2.0 | ≥ 4.0 |
| Ciprofloxacin* | 1 - 2 | > 2.0 | ≤ 1.0 | 2.0 | ≥ 4.0 |
| Danofloxacin | 0.12 - 1.0 | > 1.0 | ≤ 0.25 | - | - |
| Enrofloxacin | 0.12 - 2.0 | > 2.0 | ≤ 0.5 | 1.0 | ≥ 2.0 |
| Clindamycin | 0.25 - 16.0 | > 16.0 | ≤ 0.5 | 1.0 - 2.0 | ≥ 4.0 |
| Chloramphenicol | 2 - 16 | > 16.0 | ≤ 8.0 | 16.0 | ≥ 32.0 |
| Florfenicol | 0.25 - 8.0 | > 8.0 | ≤ 2.0 | 4.0 | ≥ 8.0 |
| Quinuptn/Dalfoptn* | 0.5 - 4 | > 4.0 | ≤ 1.0 | 2.0 | ≥ 4.0 |
| Trimetop/Sulfametx | 0.5/9.5 - 4/76 | > 4/76 | ≤ 2/38 | - | ≥ 4/76 |
| Sulfadimethoxine | 256.0 | > 256.0 | ≤ 256.0 | - | >256.0 |
| Tiamulin | 0.5 - 32.0 | > 32.0 | ≤ 16.0 | - | ≥ 32.0 |
*: applied breakpoints from CLSI document M100-S24 (CLSI 2014).