Table 1.
Meta-analyses on hepatitis B virus related hepatocellular carcinoma incidence in patients treated with interferon-a
| 1st author, year [Ref] | Studies, n | Treated patients vs. controls, n | Relative risk/Risk difference* (95% confidence interval) | P-value |
|---|---|---|---|---|
| Cammà, 2001 [6] | 7 | 853 vs 652 | All patients: -6.4%* (-10.0, -2.8) | <0.001 |
| Europeans: -4.8%* (-11.1, 1.5) | NS | |||
| Sung, 2008 [7] | 12 | 1,292 vs 1,458 | 0.66 (0.48-0.89) | 0.006 |
| Yang, 2009 [8] | 11 | 1,006 vs 1,076 | 0.59 (0.43-0.81) | 0.001 |
| Miyake, 2009 [9] | 8 | 553 vs 750 | -5.0%* (-9.4, -0.5) | 0.028 |
| Only in Asians | ||||
| Jin, 2011 [10] | 9 | 1,291 vs 1,048 | 0.47 (0.26-0.85) | <0.05 |
| 0.27 (0.06-1.03) | NS | |||
| Zhang, 2011 [11] | 2 | 176 vs 171 | 0.23 (0.05-1.04) | 0.056 |
*
Risk differences.
NS, not significant.