Table 5.

Comparison of BMD₁₀ for selected neoplasms in male and female B6C3F₁ mice and F344/N rats administered 0, 0.0875, 0.175, 0.35, or 0.70 mM glycidamide or acrylamide in the drinking water for two years.

Species	Neoplasm	Sex	Model	Glycidamide (BMD10, µmol/kg body weight/day)a	Acrylamide (BMD10, µmol/kg body weight/day)b
B6C3F1 mice	Harderian gland, adenoma	Male	Log-Logistic	5.51	5.14
			Log-Probit	5.91	5.39
		Female	Log-Logistic	4.55	6.65
B6C3F1 mice	Lung, alveolar/ bronchiolar adenoma	Male	Log-Logistic	17.16	29.59
		Female	Gamma	99.36	27.69
			Logistic	112.72	56.06
			Log-Logistic	99.08	27.15
			Log-Probit	100.00	26.89
			Multistage	98.98	27.69
			Probit	110.13	51.97
			Weibull	99.33	27.69
B6C3F1 mice	Stomach (forestomach), squamous cell papilloma	Male	Gamma	52.55	63.98
			Logistic	76.50	105.74
			Log-Logistic	51.96	62.30
			Log-Probit	49.72	60.51
			Multistage	55.10	63.98
			Probit	73.15	101.39
			Weibull	52.55	63.98
B6C3F1 mice	Mammary gland, adenoacanthoma	Female	Gamma	117.96	140.56
			Logistic	129.97	146.10
			Log-Logistic	119.46	142.80
			Log-Probit	115.08	172.55
			Multistage	116.96	140.56
			Probit	125.67	145.74
			Weibull	120.56	140.56
B6C3F1 mice	Mammary gland, adenoacanthoma or adenocarcinoma	Female	Gamma	53.46	31.22
			Log-Logistic	52.72	28.31
			Log-Probit	51.98	24.23
			Multistage	55.63	31.22
			Weibull	53.41	31.22
F344/N rats	Thyroid gland, follicular cell carcinoma	Male	Gamma	40.32	28.57
			Logistic	42.24	35.95
			Log-Logistic	39.76	27.87
			Log-Probit	70.34	26.72
			Multistage	40.32	28.57
			Probit	42.65	35.00
			Weibull	40.32	28.57
F344/N rats	Thyroid gland, follicular cell adenoma or carcinoma	Male	Gamma	19.33	20.37
			Logistic	22.62	28.19
			Log-Logistic	20.77	19.47
			Multistage	20.85	20.37
			Probit	21.65	27.14
			Weibull	20.50	20.37
		Female	Gamma	27.00	54.15
			Logistic	42.74	60.24
			Log-Logistic	24.05	54.80
			Multistage	27.00	54.15
			Probit	41.31	59.36
			Weibull	27.00	54.15
F344/N rats	Heart, malignant Schwannoma	Male	Gamma	25.06	34.13
			Logistic	31.09	37.68
			Log-Logistic	24.40	33.91
			Log-Probit	23.23	34.76
			Multistage	25.06	34.13
			Probit	30.17	37.23
			Weibull	25.06	34.13
F344/N rats	Epididymis or testes, malignant mesothelioma	Male	Gamma	11.71	29.90
			Multistage	11.59	30.66
			Probit	17.94	30.36
			Weibull	11.69	30.06
F344/N rats	Mammary gland, fibroadenoma	Female	Log-Logistic	2.39	7.74
F344/N rats	Oral mucosa or tongue, squamous cell papilloma or carcinoma	Female	Gamma	50.94	49.49
			Logistic	48.94	58.01
			Log-Logistic	51.03	48.42
			Log-Probit	50.82	61.93
			Multistage	49.97	49.49
			Probit	48.73	57.54
			Weibull	51.09	49.49

^aThe BMD₁₀ for glycidamide in µmol/kg body weight/day are from the data presented in Supplementary Table S2.

^bThe BMD₁₀ for acrylamide, in µmol/kg body weight/day, were calculated from the data presented in Beland et al. (2013).