Table I. Families of peptides identified from f8/8 library.
Lung cancer-specific phage clones recovered after the fourth round of selection with the f8/8 library in target Calu-3 cells. Phage were grouped into nine different peptide families based on a common consensus sequence (shown in bold) identified between phage clones. Orphan phage clones that did not contain a common consensus sequence between any identified clones were grouped into another family.
| ASP----- | ----GTS- | V/AD-DYS/T |
|---|---|---|
|
ASPLAAPA ASPMDVNS |
ASLPGTSQ DPTGTSAP |
GTADQDYS VDPDYTSP |
| AS/TL----Q | --LWS--- | Other |
|
ASLPGTSQ ATLWSLGQ |
ATLWSLGQ ALWSDSGA |
ANEHPMSQ DAGPMWSG DNGTFREM DTSLTTDE EMSYNADA ETMMPYGT VTDPSAST |
| ----EPGQ | -NGRP-- | |
| AMLMEPGQ ATLMEPGQ VTIPEPGQ ATVIEPGE VTGHEPGE |
VNGRAEAP ANGRPSMT ANGRPTHL ATGRPTHL |
|
| ---FSG-- | --P-LS-E | |
| APGFSGQP DNPFSGTQ |
ARPILSSE GTPLLSPE |