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. 2016 Nov;23(11):607–617. doi: 10.1101/lm.042820.116

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© 2016 Jean-Richard-dit-Bressel and McNally; Published by Cold Spring Harbor Laboratory Press

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Figure 1. — Effects of orbitofrontal cortex (OFC) inactivations. (A) OFC cannula placements as verified by Nissl-stained sections. Black dots represent the ventral point of the cannula tract, indicated on coronal sections adapted from Paxinos and Watson (2007). (B) Mean ± SEM lever-presses on the punished and unpunished levers during the last day of lever-press training (T) and punishment acquisition (sessions 1–5). Arrows indicate days that rats received infusions of either saline (n = 6) or baclofen and muscimol (BM) (n = 9) immediately prior to the session. (C) Mean ± SEM latency to initially press the punished and unpunished lever (averaged across trials) during punishment acquisition. (D) Mean ± SEM lever-press ratios of BM on lever pressing during punishment expression (n = 15). (E) Mean ± SEM latency to initially press the punished and unpunished lever (averaged across trials) during punishment expression after infusions of saline or BM. (F) Mean ± SEM magazine entries during punishment expression after infusions of saline or BM. (G) Mean ± SEM lever–press ratios of BM on lever pressing during aversive choice (n = 15). (H) Mean ± SEM latency to initially press the punished and unpunished levers during choice test after infusions of saline or BM. (I) Mean ± SEM magazine entries during choice test after infusions of saline or BM. (*) P < 0.05.