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Model of HSF-1 transcription activation in larval development and the HSR. (A) Schematic of an HSF-1 developmentally activated promoter showing binding of EFL-1(E2F)/DPL-1(DP) to the GC-rich motif to function as an activator by enhancing the binding of HSF-1 to a degenerate HSE, resulting in transcriptional activation. (B) Schematic of classical heat-shock-responsive gene in which multiple HSF-1 trimers bind to tandem canonical HSEs, leading to inducible transcription.
