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. 2016 Nov;22(11):1643–1662. doi: 10.1261/rna.057927.116

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© 2016 Greber; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 9. — Blocking, probing, and proofreading of functional centers during cytoplasmic 60S maturation. Schematic footprints of assembly and maturation factors that are released or act during cytoplasmic maturation of the 60S subunit are indicated. (A) Nmd3 and eIF6 block access to the subunit interface and the SRL while Mrt4 functions as a placeholder for the P-stalk protein P0. SBDS and EFL1 proofread the PTC, the SRL, and the P-stalk during eIF6 release. (B) Rei1 and Jjj1 probe the exit tunnel and the RAC binding site during release of Arx1, which likely functions mostly in shielding access to the tunnel at these late stages of maturation.