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. 2016 Nov;22(11):1728–1738. doi: 10.1261/rna.057935.116

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© 2016 Ruff et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 4. — Singlet riboswitches require conserved A-minor tertiary interactions with an adjacent “ghost-aptamer” domain. (A) Diagrams highlighting the conserved helical regions and A-rich bulges in the Lmo and Dha riboswitches. (B) Structural model of the conserved A-minor interaction from the F. nucleatum tandem riboswitch (Butler et al. 2011). (C,D) Diagrams and glycine-binding curves for singlet mutants with disrupted A-minor interactions. (E) MALS analysis of Dha Trn refolded in the presence of saturating glycine, showing that the major species is an alternative dimer conformation.