Table 2.
Chemotherapeutics used to treat breast cancer
| Drug class | Mechanism of action | Example | Reference |
|---|---|---|---|
| Anthracyclines |
Inhibition of DNA and RNA synthesis Disruption of DNA damage response Inhibition of Topoisomerase II |
Doxorubicin Epirubicin Mitoxantrone |
49 |
| Taxanes | Disruption of microtubule function |
Docetaxel Paclitaxel |
50 |
| Alkylating Agent: Nitrogen Mustard | Interference with DNA replication | Cyclophosphamide | 40 |
| Anti‐metabolites | Prevention of folate use for DNA generation |
Methotrexate Fluorouracil Capecitabine |
51 |
| Anti‐HER2/EGFR |
Tyrosine kinase inhibition Arrest of cell cycle Suppression of angiogenesis |
Trastuzumab Pertuzumab Lapatinib |
52 |