Table 1.

Comparisons of dominant features of patients with PSEN1 L226F

Case	Zekanowski et al (2006)25	Gomez-Tortosa et al (2010)27	Korean patient
Age of onset	33 years	33 years	37 years
Family history	Yes; mother, clinical YOD	Yes; father, clinical YOD	None
Symptoms	Early behavioral, frontal signs, subsequent severe recent memory loss, mild parkinsonism, progress to mutism	Early depression, dysarthria, nonfluent aphasia, cognitive declines, subsequent Parkinsonism	Early paranoid ideation and anxiety, cognitive decline, nonfluent aphasia progress to mutism, late Parkinsonism
Neuroimaging characteristics	Frontal atrophy on CT; severe hypoperfusion in frontal areas on SPECT	Diffuse cortical atrophy on MRI	Diffuse cortical atrophy on MRI; marked cortical hypometabolism especially in bilateral parietal regions on FDG-PET
Age of death	38 years	42 years	44 years
Autopsy	AD pathology	AD pathology	Not done

Abbreviations: AD, Alzheimer’s disease; CT, computerized tomography; FDG-PET, fluorodeoxyglucose glucose positron emission tomography; MRI, magnetic resonance imaging; YOD, young-onset dementia.