Table 1.
Case | Zekanowski et al (2006)25 | Gomez-Tortosa et al (2010)27 | Korean patient |
---|---|---|---|
Age of onset | 33 years | 33 years | 37 years |
Family history | Yes; mother, clinical YOD | Yes; father, clinical YOD | None |
Symptoms | Early behavioral, frontal signs, subsequent severe recent memory loss, mild parkinsonism, progress to mutism | Early depression, dysarthria, nonfluent aphasia, cognitive declines, subsequent Parkinsonism | Early paranoid ideation and anxiety, cognitive decline, nonfluent aphasia progress to mutism, late Parkinsonism |
Neuroimaging characteristics | Frontal atrophy on CT; severe hypoperfusion in frontal areas on SPECT | Diffuse cortical atrophy on MRI | Diffuse cortical atrophy on MRI; marked cortical hypometabolism especially in bilateral parietal regions on FDG-PET |
Age of death | 38 years | 42 years | 44 years |
Autopsy | AD pathology | AD pathology | Not done |
Abbreviations: AD, Alzheimer’s disease; CT, computerized tomography; FDG-PET, fluorodeoxyglucose glucose positron emission tomography; MRI, magnetic resonance imaging; YOD, young-onset dementia.