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. 2016 Feb 2;5(4):296–305. doi: 10.1002/cpdd.240

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© 2016, The Authors. Clinical Pharmacology in Drug Development Published by Wiley Periodicals, Inc. on behalf of The American College of Clinical Pharmacology

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Change in VEGF (A, C) plasma and (B, D) serum concentrations: 7‐day study—stage 1 and stage 2. Levels of plasma or serum levels of VEGF measured by ELISA on day 1 and day 7 at specified times in subjects dosed daily for 7 days with placebo, 0.3, 0.6, or 1.2 mg/kg twice daily.