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. 2016 Oct 17;26(11):4253–4264. doi: 10.1093/cercor/bhw263

Figure 1.

Figure 1.

Synaptic transmission and neural excitability are altered in PD and dyskinesia in direct striatal projection neurons. (A) Number of dendritic spines in 10 µm of D1-MSNs. (B) Number of action potential (AP) as a function of injected current intensity in D1-MSNs. Top, representative examples of firing rate at 0.4 nA of injected current. Scale bar = 50 mV/50ms. (C) Evoked-EPSP amplitude values across stimulus intensity in D1-MSNs. Top, representative examples of evoked EPSPs at 20, 40, and 60 µA. Scale bar 10 mV/20ms. (D) Illustrative traces of APs evoked by synaptic stimulation in each experimental condition in D1-MSNs (left) Summary of changes in the threshold of synaptically evoked APs; (*γP < 0.05, **γγP < 0.005 parkinsoninan or dyskinetic mice respectively vs. sham-lesioned; one-way ANOVA).