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. 2016 Oct 17;26(11):4253–4264. doi: 10.1093/cercor/bhw263

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Synaptic transmission and neural excitability are altered in PD and dyskinesia in indirect striatal projection neurons. (A) Spine density (number of spines in 10 µm) in D2-MSNs. (B) Firing rate of D2-MSNs. Top, representative firing rate at 0.4 nA of injected current. Scale bar = 50 mV/50ms. (C) Synaptic transmission of D2-MSNs remains decreased in dyskinetic mice. Top, representative EPSP-stimulus intensity at 20, 40 and 60 µA. Scale bar = 10 mV/20ms. (D) Illustrative traces of APs evoked by synaptic stimulation in each experimental condition in D2-MSNs (left). Summary of changes in the threshold of synaptically evoked APs (right). (*γP < 0.05, **γγ P < 0.005 parkinsoninan or dyskinetic mice respectively vs. sham-lesioned; one-way ANOVA).