Table 3.
Intrinsic membrane properties of MSNs. Data presented as mean ± SEM. The number of MSNs-recorded in each condition is expressed in parentheses following the condition. *P < 0.05; **P < 0.01 vs. sham-lesioned
| D1-MSNs | D2-MSNs | |||||
|---|---|---|---|---|---|---|
| Sham (7) | Park (8) | Dysk (13) | Sham (9) | Park (8) | Dysk (11) | |
| Passive membrane properties | ||||||
| RMP (mV) | −83.8 ± 3.9 | −83.8 ± 2.5 | −85.5 ± 3.1 | −88.2 ± 2.6 | −89.5 ± 2.3 | −88.7 ± 1.7 |
| Rin (mΩ) | 42.8 ± 5.4 | 45.6 ± 4.3 | 46.0 ± 3.7 | 46.8 ± 3.8 | 47.6 ± 0.5 | 48.4 ± 5.7 |
| Active membrane properties | ||||||
| AP | ||||||
| Threshold (mV) | −46.8 ± 0.5 | −53.5 ± 2.7* | −51.1 ± 2.1 | −48.8 ± 2.3 | −48.9 ± 1.7 | −49.3 ± 2.8 |
| Amplitude (mV) | 88.2 ± 7.3 | 76.2 ± 5.6 | 88.6 ± 5.4 | 87.0 ± 5.3 | 85.4 ± 10.3 | 91.1 ± 6.4 |
| Width (ms) | 0.76 ± 0.07 | 0.91 ± 1.01 | 0.89 ± 0.08 | 0.76 ± 0.07 | 0.89 ± 0.02 | 0.82 ± 0.08 |
| AHP Amplitude (mV) | −4.9 ± 1.2 | −7.5 ± 0.9 | −6.9 ± 1.3 | −4.6 ± 0.9 | −5.1 ± 0.5 | −8.6 ± 0.9 |
| Rheobase (nA) | 0.46 ± 0.06 | 0.33 ± 0.05 | 0.29 ± 0.04* | 0.46 ± 0.05 | 0.24 ± 0.03** | 0.29 ± 0.03* |