Table 5.
Drug content, fine particle fraction (FPF), mass median aerodynamic diameter (MMAD), and emitted dose (ED) of the CIP-containing microparticle compositions investigated
| DPI | Drug content (%) | FPF (%) | MMAD (µm) | ED (%) |
|---|---|---|---|---|
| CIP_SPD | 100±0 | 31.68±1.4 | 7.23±0.01 | 99.95±0.5 |
| CIP_PVA_SPD | 85±0.07 | 60.18±1.3 | 3.61±0.05 | 95.92±0.4 |
| CIP_CD_SPD | 59±0.03 | 58.54±1.1 | 3.19±0.01 | 96.93±0.5 |
| CIP_LEU_SPD | 72±0.08 | 80.27±1.7 | 2.15±0.08 | 95.81±0.6 |
| CIP_PVA_CD_LEU_SPD | 45±0.24 | 45.93±1.4 | 4.53±0.02 | 97.68±0.4 |
Abbreviations: PVA, polyvinyl alcohol; CIP, ciprofloxacin hydrochloride; LEU, l-leucine; CD, cyclodextrin; SPD, spray drying.