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The activation of redox-mediated Nrf2 signaling pathway.
Notes: The mRNA expressions of Nrf2 and its key downstream genes, including SOD2, NQO1, TXN-1, TXNRD-1, GCLC, and hsp70, were measured through quantitative real-time PCR. Data are expressed as mean ± SD from three independent experiments. *P<0.05 vs control; #P<0.05 for SiNPs vs SiNPs + NAC.
Abbreviations: PCR, polymerase chain reaction; SD, standard deviation; SiNPs, silica nanoparticles; NAC, N-acetylcysteine.
