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. 2016 Oct 11;11:5257–5276. doi: 10.2147/IJN.S112030

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© 2016 Guo et al. This work is published and licensed by Dove Medical Press Limited

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The loss of MMP induced by SiNPs and suppressed by NAC.

Notes: HUVECs were treated with 50 μg/mL SiNPs for 24 hours plus NAC pretreatment for 2 hours. The MMP was determined using the fluorescent probe, JC-1. (A) Confocal images of MMP at a magnification of ×1,200. (B) The JC-1 red/green fluorescence intensity ratio was used to express the changes of MMP, and the decreased ratio indicates decrease of MMP. Data are expressed as mean ± SD from three independent experiments. *P<0.05 vs control; ^#P<0.05 for SiNPs vs SiNPs + NAC.

Abbreviations: MMP, mitochondrial membrane potential; SiNPs, silica nanoparticles; NAC, N-acetylcysteine; HUVECs, human umbilical vein endothelial cells; SD, standard deviation; DAPI, 4′,6-diamidino-2-phenylindole.