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. 2016 Oct 11;11:5257–5276. doi: 10.2147/IJN.S112030

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© 2016 Guo et al. This work is published and licensed by Dove Medical Press Limited

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Regulation of MAPK/Bcl-2 and PI3K/Akt/mTOR signaling.

Notes: The expressions of ERK, p-ERK, p38 MAPK, p-p38 MAPK, JNK, p-JNK, PI3K, p-PI3K, Akt, p-Akt, mTOR, p-mTOR, bcl-2, and Bax were measured by Western blot assay after 24 hours of exposure to SiNPs plus NAC in HUVECs. (A) All blots shown are representative of three independent experiments. (B) Relative densitometric analysis of the protein bands was performed and presented. Data are expressed as the mean ± SD from three independent experiments. *P<0.05 vs control; ^#P<0.05 for SiNPs vs SiNPs + NAC.

Abbreviations: SiNPs, silica nanoparticles; NAC, N-acetylcysteine; HUVECs, human umbilical vein endothelial cells; SD, standard deviation.