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. Author manuscript; available in PMC: 2016 Oct 17.
Published in final edited form as: Adv Radiol. 2015;2015:206405. doi: 10.1155/2015/206405

Figure 12.

Figure 12

Relaxation-based MRI of Gd-DOTA-4Amp and DyDOTP can measure tumor pHe. (a) The change in water linewidth before injection (left) and after injection (right) is used to estimate the concentration of the agent. (b) A parametric map of the r1 relaxivity of the agent in a glioma model is obtained from a T1-weighted MR images and the concentration of the agent. (c) The r1 relaxivity of the agent is pH-dependent, (d) which can be used to convert the r1 relaxivity map to a pH map (color scale bar shows pH units). Reproduced from [53] with permission.