Table 6.
Response of TKI in patients with E709X EGFR mutations in the study and in literature
| Mutations | Exon | Total cases | Responder to TKI | Non-responder to TKI |
|---|---|---|---|---|
| DelE709-T710 | 18 | 1 | 1 (32) | |
| DelE709-T710insD | 18 | 6 | 1 (21) | 5 (this study) |
| E709Q | 18 | 1 | 1 (13) | |
| E709A + G719C | 18 | 5 | 1 (this study), 1 (33), 1 (34) | 1 (this study), 1 (35) |
| E709A + G719S | 18 | 1 | 1 (36) | |
| E709A + L858R | 18+21 | 2 | 1 (this study) | 1 (this study) |
| E709A + L861G | 18+21 | 1 | 1 (36) | |
| E709G + G719C | 18 | 1 | 1 (this study) | |
| E709G + Del exon19 | 18+19 | 1 | 1 (this study) | |
| E709G + L858R | 18+21 | 6 | 2 (this study), 2 (37) | 1 (this study), 1 (37) |
| E709H + G719C | 18 | 1 | 1 (5) | |
| E709K + G719A | 18 | 1 | 1 (38) | |
| E709K + G719C | 18 | 1 | 1 (20) | |
| E709K + G719S | 18 | 1 | 1 (this study) | |
| E709K + L858R | 18+21 | 4 | 2 (this study), 1 (12), 1 (20) | |
| E709V + L858R | 18+21 | 1 | 1 (this study) |
Note: Number (reference number).
Abbreviations: EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor.