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. 2016 Oct 11;9:6195–6201. doi: 10.2147/OTT.S115309

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© 2016 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Induction of both apoptosis and autophagy by lapatinib in vitro.

Notes: (A) CNE-2 and HONE-1 cells were treated with lapatinib (0–10 μM) or DMSO control for 48 hours. Annexin V-APC/7-AAD double staining was performed to detect apoptotic activity, and the results are displayed as histograms. Each bar represents the mean ± standard deviation. *P<0.05; **P<0.01. (b) CNE-2 and HONE-1 cells were treated with lapatinib (0–10 μM) or DMSO control for 48 hours. (B) Cleaved-PARP and LC3 A/B were examined by western blotting. GAPDH was used as a loading control.