Hat1/Hat2 complex. (a) Uncomplexed Hat1(green) overlaid with Hat1/Hat2 complex (Hat1 in marine, Hat2 in gold, Hat1200–208 loop in red, CoA in yellow, and histone H41–48 in pink). The region containing the conserved core is indicated. (PDB codes: 2P0W and 4PSW). (b) Zoomed in view of select interactions between Hat1 and Hat2. Left- Interactions between Hat1 loop and Hat2. Right- Interactions between Hat1, Hat2, and histone H4 peptide. (c) Linear representation of select Hat1, Hat2, and H4 peptide interactions. Dashed lines represent interactions. Domain and secondary structure naming correspond to primary texts.