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. Author manuscript; available in PMC: 2016 Oct 17.
Published in final edited form as: ACS Chem Biol. 2015 Dec 2;11(3):632–642. doi: 10.1021/acschembio.5b00841

Table 1.

Autoacetylation of HATs

Protein Relevant autoacetylated lysine(s) Functions of acetylation
p300 K1499, K1549, K1554, K1560

  • activates enzyme

  • regulates autoinhibitory loop

  • decreases Km for AcCoA and substrate peptide
MOF K274

  • activates enzyme

  • decreases Km for substrate peptide

  • increases kcat

  • maintains loops conformation

  • conserved throughout MYST family
Rtt109 K290

  • activates enzyme

  • decreases Km for AcCoA

  • increases kcat
PCAF K416, K428, K430, K431, K442

  • 2–3 fold increase in catalytic activity

  • increases structural stability

  • localizes PCAF to nucleus

Only autoacetylated lysines with a known effect on enzyme biochemistry have been listed. MOF has been listed as a representative member of the MYST family.