Table 1.
Exposure Effects based on Genotype
| BDNF val/val N = 134 |
BDNF val/met or met/met N = 751 |
Genotype × Exposure |
|||||
|---|---|---|---|---|---|---|---|
| Unexposed N = 102 |
Exposed N = 32 |
Chi- Square2, p value |
Unexposed N = 50 |
Exposed N = 25 |
Chi- Square2, p value |
Chi- Square3, p value |
|
| N (%) | N (%) | N (%) | N (%) | ||||
|
Internalizing Disorders |
|||||||
| Major Depressive Disorder |
51 (50) | 19 (38) | χ2 = 1.94, p = 0.16 |
15 (46) | 16 (64) | χ2 = 1.65, p = 0.19 |
χ2 = 3.38, p = 0.067 |
| Any Mood Disorder5 |
68 (66) | 27 (54) | χ2 = 2.29, p= 0.13 |
24 (75) | 16 (64) | χ2 = 0.84, p = 0.37 |
χ2 = 0.0002, p = 0.9 |
| Any Anxiety Disorder6 |
56 (55) | 31 (62) | χ2 = 0.69, p = 0.40 |
16 (50) | 14 (56) | χ2 = 0.20, p = 0.65 |
χ2 = 0.0065, p = 0.93 |
| Any Internalizing Disorder |
80 (78) | 37 (74) | χ2 = 0.37, p = 0.54 |
26 (81) | 20 (80) | χ2 = 0.01, p = 0.91 |
χ2 = 0.04, p = 0.83 |
|
Externalizing Disorders |
|||||||
| Any Disruptive Use Disorder7 |
26 (25) | 12 (24) | χ2 = 0.04, p = 0.84 |
11 (34) | 14 (56) | χ2 = 2.66, p = 0.10 |
χ2 = 2.04, p = 0.15 |
| Conduct Disorder |
18 (18) | 5 (10) | χ2 = 1.52, p = 0.21 |
7 (22) | 13 (52) | χ2 = 5.59 p = 0.018 |
χ2 = 6.64, p = 0.01 |
| ADHD | 6 (6) | 3 (6) | -4 | 6 (18) | 2 (8) | -4 | -4 |
| ODD | 3 (3) | 4 (8) | -4 | 1 (3) | 0 | -4 | -4 |
| Any Substance Use Disorder8 |
45 (44) | 12 (24) | χ2 = 5.79, p = 0.016 |
13 (41) | 18 (72) | χ2 = 5.57, p = 0.018 |
χ2 = 10.97, p = 0.0009 |
| Nicotine Dependence |
24 (24) | 10 (20) | χ2 = 0.24, p = 0.62 |
15 (46) | 7 (28) | χ2 = 2.11, p = 0.14 |
χ2 = 0.74, p = 0.38 |
| Any externalizing Disorder |
52 (51) | 19 (38) | χ2 = 2.30, p = 0.13 |
17 (53) | 20 (80) | χ2 = 4.51, p = 0.036 |
χ2= 6.68, p = 0.0097 |
1
Includes 65 val/met and 10 met/met.
2
Chi-square; degree of freedom = 1.
3
Chi-Square, based on Breslow-Day test for homogeneity of Odds Ratios; degrees of freedom = 1.
4
Not estimable due to low Ns.
5
Includes major depression, dysthymia, and minor depressive disorder
6
Includes generalized anxiety disorder, obsessive compulsive disorder, panic disorder, posttraumatic stress disorder, social anxiety disorder (social phobia), specific phobia,
7
Includes conduct disorder, attention deficit hyperactivity disorder (ADHD), and oppositional defiant disorder (ODD).
8
includes drug abuse or dependence, or alcohol abuse or dependence, but not nicotine dependence