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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Cytokine. 2016 Aug 27;88:62–70. doi: 10.1016/j.cyto.2016.08.024

Figure 6.

Figure 6

Overall topology of the MIF/CD74 complex as predicted by ZDOCK. a) Amino acid residues involved in the hot spot contributed by CD74 (left panel, residues Y118 and G119 in blue and surrounding hydrophilic residues in orange) and the corresponding MIF binding site for CD74 colored in yellow (right panel). Models of the whole molecules are not at the same scale. b) Overall topology of the MIF (yellow) and CD74 (blue) complex. c) Amino acid residues Y118 and G119 involved in the hot spot contributed by CD74 are in blue. Residues in orange represent the CD74 hydrophilic ring surrounding the hydrophobic core.