Table 1.

Increased and Decreased IPA® Diseases and Functions

Toxicant	Diseases or Functions	Predicted Activation State	z-score	Num. of DEGs
ATR	colony formation of cells	Increased	2.49	7
	proliferation of connective tissue cells	Increased	2.27	6
	development of body trunk	Increased	2.20	7
	cellular homeostasis	Increased	2.13	9
	colony formation of tumor cell lines	Increased	2.13	5
	secretion of molecule	Decreased	−2.00	5
	cell proliferation of fibroblasts	Increased	2.00	4
	flux of Ca2+	Increased	1.98	4
DEHP	damage of lung	Increased	1.97	4
	size of tumor	Increased	1.96	4
PFOA	cellular infiltration by leukocytes	Increased	2.21	5
	injury of lung	Increased	1.98	4
	necrosis of liver	Increased	1.98	4
	Hypertrophy	Increased	1.98	5
TBT	development of body trunk	Increased	2.35	13
	development of hematopoietic system	Increased	2.22	7
	development of lymphatic system	Increased	2.15	8
	binding of DNA	Increased	2.10	12
	binding of protein binding site	Increased	2.08	7
	neoplasia of cells	Decreased	−2.07	16