Table 2.

Predicted Upstream Regulators

Toxicant	Upstream Regulator	z-score1	Num. Target DEGs
ATR	cycloheximide	2.59	8
	EGF	2.57	7
	HMGA1	2.24	5
	atorvastatin	2.24	5
	Pdgf (complex)	2.22	5
	fulvestrant	−2.21	5
	VEGFA	2.03	7
	Pkg	2.00	4
	dalfampridine	2.00	4
	FOXO3	2.00	5
	amphetamine	1.99	4
	kainic acid	1.99	4
	Pka	1.99	4
	salirasib	1.98	4
	EPAS1	−1.98	6
	MAPK3	1.98	4
	CREB1	1.98	7
	CD38	−1.98	4
	EPO	1.97	5
	CSF3	1.97	4
	LIF	1.97	4
	Akt	−1.96	4
DEHP	AGT	−2.87	10
	lipopolysaccharide	−2.73	13
	NUPR1	−2.63	7
	HIF1A	−2.53	13
	IFNG	−2.48	15
	IL5	−2.45	6
	E. coli B5 lipopolysaccharide	−2.43	6
	RELA	−2.43	6
	SREBF1	−2.37	7
	progesterone	−2.27	8
	fluticasone	−2.24	5
	fulvestrant	−2.21	5
	LEP	−2.21	6
	hydrogen peroxide	−2.21	6
	CTNNB1	−2.19	5
	Mek	−2.19	5
	SB203580	2.19	5
	CAT	2.18	5
	Ins1	−2.18	5
	N-acetyl-L-cysteine	2.18	5
	PDGF BB	−2.15	8
	deferoxamine	−2.05	10
	TP53	−2.05	17
	IL1B	−2.04	9
	LY294002	2.01	11
	Akt	−2.00	8
	Ifn	−2.00	5
	trovafloxacin	−2.00	4
	KLF2	2.00	4
	mifepristone	1.99	5
	FSH	1.98	6
	raloxifene	−1.98	4
	TGFBR2	−1.97	4
	P38 MAPK	−1.97	5
	LDL	−1.97	4
	estrogen	−1.96	6
	paclitaxel	−1.96	6
PFOA	HIF1A	−3.19	15
	salirasib	2.81	8
	Akt	−2.59	7
	NUPR1	−2.50	13
	CD38	−2.43	6
	MYC	−2.35	9
	fulvestrant	−2.22	5
	cobalt chloride	−2.20	5
	cycloheximide	2.00	9
	Pkg	2.00	4
	ERBB4	−2.00	4
	resveratrol	2.00	5
	KLF2	2.00	4
	metribolone	−1.98	5
	NOTCH1	−1.98	4
	ARNT	−1.97	7
	SREBF1	−1.96	6
TBT	IL10RA	2.65	7
	salirasib	2.63	7
	HIF1A	−2.62	21
	CD38	−2.62	7
	cycloheximide	2.39	7
	cobalt chloride	−2.22	5
	ESR2	2.22	9
	STAT4	−2.21	5
	NUPR1	−2.20	13
	lithium chloride	2.20	6
	trichostatin A	2.20	7
	EPO	2.19	6
	Akt	−2.19	5
	Growth hormone	2.18	5
	BMP4	−2.12	6
	EPAS1	−2.01	13
	ACVR1C	2.00	4
	Pkg	2.00	4
	COMMD1	2.00	4
	F3	2.00	5
	SB-431542	−1.99	5
	di(2-ethylhexyl) phthalate	1.98	4
	NOTCH1	−1.98	5
	CREBBP	1.98	5
	CSF3	1.97	4

¹Upstream regulators with z-score > 1.96 are predicted to be activated, upstream regulators with z-score < −1.96 are predicted to be inhibited.