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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Reprod Toxicol. 2016 Sep 7;65:382–393. doi: 10.1016/j.reprotox.2016.09.001

Table 3.

Differentially expressed genes affected by two or more toxicant treatments

Toxicant treatments Common upregulated genes Num. of genes1
ATR DEHP PFOA FAIM, GSTK1 2 = 16.7% of 12
ATR PFOA TBT EGR1, FOS, FOSB 3 = 25.0% of 12
ATR DEHP FAIM, GSTK1, ZGRF1 3 = 25.0% of 12
ATR PFOA EGR1, FAIM, FOS, FOSB, GSTK1, TRIB3 6 = 50.0% of 12
ATR TBT EGR1, EGR3, EPB41L4A, FOS, FOSB 5 = 29.4% of 17
DEHP PFOA FAIM, GSTK1, PARP12, RPUSD3, ZNF280D 5 = 41.7% of 12
PFOA TBT EGR1, FOS, FOSB 3 = 25.0% of 12
Toxicant treatments Common downregulated genes Num. of genes1
ATR DEHP PFOA TBT ANKRD1, CCDC184, EGLN1, HK2, KDM3A, RIMKLA, SLFN5, STC1 8 = 21.1% of 38
ATR DEHP PFOA ANKRD1, CCDC184, EGLN1, HK2, KDM3A, RIMKLA, SLFN5, STC1 8 = 21.1% of 38
ATR DEHP TBT ANKRD1, CCDC184, EGLN1, HIST1H4C, HK2, KDM3A, RIMKLA, SLFN5, STC1 9 = 23.7% of 38
ATR PFOA TBT AK4, ANKRD1, CCDC184, CLDN14, EGLN1, FAM162A, HELZ, HERC3, HK2, KDM3A, NRN1, PFKFB4, PTX3, RAB2B, RIMKLA, RIOK3, SAP30, SLC2A1, SLFN5, STC1, TNIP1, UPRT, ZNF395 23 = 60.5% of 38
DEHP PFOA TBT ANKRD1, BHLHE40, BHLHE41, CCDC184, EGLN1, HK2, HMGCS1, KDM3A, PTPRB, RIMKLA, SLFN5, STC1 12 = 27.9% of 43
ATR DEHP ANKRD1, CAV1, CCDC184, EGLN1, GTF3C6, HIST1H2AC, HIST1H4C, HK2, KDM3A, RIMKLA, SLFN5, STC1 12 = 31.6% of 38
ATR PFOA ACTA1, AK4, ANKRD1, CCDC184, CLDN14, EGLN1, FAM162A, HELZ, HERC3, HK2, KDM3A, NRN1, PFKFB4, PTX3, RAB2B, RIMKLA, RIOK3, SAP30, SLC2A1, SLFN5, STC1, TNIP1, UPRT, ZNF395 24 = 63.2% of 38
ATR TBT AK4, ALKBH5, ANKRD1, CCDC184, CLDN14, DDX58, EGLN1, FAM162A, HELZ, HERC3, HIST1H4C, HK2, KDM3A, NRN1, PFKFB4, PTX3, RAB2B, RIMKLA, RIOK3, SAP30, SLC2A1, SLFN5, STC1, TNIP1, UPRT, ZNF395 26 = 68.4% of 38
DEHP PFOA ADM, ANKRD1, BHLHE40, BHLHE41, CCDC184, EGLN1, HK2, HMGCS1, IGFBP5, KDM3A, MKRN3, PTPRB, RIMKLA, SERPINB6, SERPINE1, SLFN5, STC1, TFRC 18 = 41.9% of 43
DEHP TBT ANKRD1, BHLHE40, BHLHE41, CCDC184, EGLN1, HIST1H4C, HK2, HMGCS1, KDM3A, NAMPT, PTPRB, RIMKLA, SLFN5, STC1 14 = 29.2% of 48
PFOA TBT ADAMTS20, AK4, ANKRD1, BHLHE40, BHLHE41, CCDC184, CHL1, CLDN14, EGLN1, FAM162A, HELZ, HERC3, HK2, HMGCS1, KCTD12, KDM3A, LRRC58, MAP3K1, NRN1, P4HA1, PFKFB4, PTPRB, PTX3, RAB2B, RIMKLA, RIOK3, SAP30, SLC2A1, SLFN5, STC1, TNIP1, UPRT, ZNF395 33 = 76.7% of 43
1

Fraction (%) of common genes is relative to the size of the smallest gene set included in the intersection.