Figure 1.

Sarcopenia is associated with myofiber atrophy. A) Age-related changes in AT muscle mass, normalized to BW. *P < 0.05 compared to values from other age groups (n = 6–8 mice per group). B) Transverse section of AT muscle from 18-mo-old mouse stained with WGA (5 μg/ml, red), to visualize extracellular matrix and to assess total fiber numbers and CSA of individual fibers. Scale bar, 500 μm. C) Number of muscle fibers in AT muscle from 18- and 28-mo-old mice. D) Average fiber CSA of individual fibers from AT muscle of 18- and 28-mo-old mice. *P < 0.05 compared to values from 18-mo-old mice (n = 6–8 mice per group).