Fig. 3.

a–d The representative appearance of alendronate-induced gastric lesions in the rat stomach compromised or not with mild water immersion and restraint stress (WRS) with or without i.g. pretreatment with CORM-2 (5 mg/kg) or NaHS (5 mg/kg). Note, the presence of superficial gastric lesions mainly localized in antral part of gastric mucosa in rat stomach exposed to alendronate (300 mg/kg i.g.) (a). In gastric mucosa compromised by mild WRS and administered with alendronate (300 mg/kg i.g.) additionally to damage in antrum, the numerous dot-like and band-like lesions are visible in oxyntic mucosa (b). In rats pretreated with CORM-2 (c) or NaHS (d), the total area of alendronate-induced gastric lesions compromised by mild WRS is markedly reduced (b, c, d)