Fig. 8.

a, b Expression of mRNA for iNOS (a) and COX-2 (b) in gastric mucosa of intact rats or those exposed to mild water immersion and restraint stress (WRS) alone or administered with alendronate (300 mg/kg i.g.) alone or those exposed to the combination of mild WRS and alendronate (300 mg/kg i.g.) with or without pretreatment with CORM-2 (5 mg/kg i.g.) or NaHS (5 mg/kg i.g.). Results are expressed as the iNOS and COX-2 mRNA expression normalized to β-actin. Results are mean ± SEM of 4-8 determinations per group. Asterisk indicates a significant change (p < 0.05) as compared with the respective values in intact gastric mucosa. Cross indicates significant change (p < 0.05) as compared with the values obtained vehicle-control gastric mucosa compromised by mild WRS and administered with alendronate (300 mg/kg i.g.)