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. 2016 Oct 4;2016:8928530. doi: 10.1155/2016/8928530

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Copyright © 2016 Fuxing Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MMP-9-induced tight junction disruption and endothelial coculture system hyperpermeability were not attenuated by IL-1β inhibition. (a) The levels of IL-1β were significantly higher in BzATP groups than in control groups (^∗ P < 0.05). However, batimastat + BzATP treatment did not alter the level of IL-1β versus BzATP group (^∗∗ P > 0.05). (b) Exposure to BzATP significantly increased the permeability to FITC-dextran compared with the control groups (^∗ P < 0.05). Batimastat attenuated BzATP-induced paracellular permeability versus BzATP group (^∗∗ P < 0.05). (c) Confocal microscopy images of immunofluorescence staining of ZO-1 and occludin demonstrating the protective effect of batimastat against BzATP-induced tight junction disruption.