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. 2016 Oct 18;7:1655. doi: 10.3389/fmicb.2016.01655

FIGURE 1.

FIGURE 1

Phylogeny of Vpx/Vpr proteins derived from various human immunodeficiency viruses/simian immunodeficiency viruses (HIV/SIVs). Phylogenetic tree based on diverse Vpx/Vpr proteins was constructed as previously described (Sakai et al., 2016), and is shown together with SAMHD1 (sterile alpha motif and HD-domain containing protein 1)-degrading activity. Viral clones with/without SAMHD1-degrading activity (Laguette et al., 2012; Lim et al., 2012) are indicated by blue and red letters, respectively. Note that Vpr proteins from HIV-2 type viruses (HIV-2, SIVsmm/mac/mne/stm, and SIVrcm/mnd-2/drl) are excluded from this tree for simplicity and clarity. Branches were calculated from 1000 bootstrap replicates, and the bootstrap values are labeled on the major branches. Scale bar represents the genetic distance. For virus designations, origins, and types, see the text (Introduction). Amino acid sequences were obtained from the HIV sequence database at Los Alamos National Laboratory (http://www.hiv.lanl.gov) or from the GenBank (http://www.ncbi.nlm.nih.gov).